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Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies

only administered GLP-1-MK-801 to animals for up to two weeks, so its long-term efficacy and safety require further validation

Health 72 McLeanA

Traumatic brain injury (TBI) The evolution of TBI is accompanied by biological processes, such as iron accumulation, disordered iron metabolism, upregulation of ferroptosis-related genes, decreased GPX activity and ROS accumulation 75